Journal: American Journal of Human Genetics

Article Title: Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

doi: 10.1016/j.ajhg.2019.02.022

Figure Lengend Snippet: Independent SNP Associations with Risk of COA Discovered in the UK Biobank Study (13,962 Affected Individuals versus 300,671 Controls) and Validated in the 23andMe Study (31,759 Affected Individuals versus 214,890 Controls)

Article Snippet: At least five sentinel SNPs are likely to represent COA-specific risk factors ( A) because they were not associated with AOA risk (OR ∼1 in the meta-analysis of UK Biobank and 23andMe studies; Table S9 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Association between Sentinel Variants and Risk of COA and AOA The two panels (A and B) respectively show results for COA and AOA sentinel SNPs that were identified in the UK Biobank GWAS and that were subsequently validated in the 23andMe replication study.

Techniques:

Journal: American Journal of Human Genetics

Article Title: Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

doi: 10.1016/j.ajhg.2019.02.022

Figure Lengend Snippet: Independent SNP Associations with Risk of AOA Discovered in the UK Biobank Study (26,582 Affected Individuals versus 300,671 Controls) and Validated in the 23andMe Study (16,297 Affected Individuals versus 217,711 Controls)

Article Snippet: At least five sentinel SNPs are likely to represent COA-specific risk factors ( A) because they were not associated with AOA risk (OR ∼1 in the meta-analysis of UK Biobank and 23andMe studies; Table S9 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Association between Sentinel Variants and Risk of COA and AOA The two panels (A and B) respectively show results for COA and AOA sentinel SNPs that were identified in the UK Biobank GWAS and that were subsequently validated in the 23andMe replication study.

Techniques:

Journal: American Journal of Human Genetics

Article Title: Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

doi: 10.1016/j.ajhg.2019.02.022

Figure Lengend Snippet: Genes with a Sentinel eQTL and/or Non-Synonymous SNP in LD (r2 ≥ 0.8) with Sentinel Asthma Risk Variants Identified in the GWAS of COA or AOA

Article Snippet: At least five sentinel SNPs are likely to represent COA-specific risk factors ( A) because they were not associated with AOA risk (OR ∼1 in the meta-analysis of UK Biobank and 23andMe studies; Table S9 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Association between Sentinel Variants and Risk of COA and AOA The two panels (A and B) respectively show results for COA and AOA sentinel SNPs that were identified in the UK Biobank GWAS and that were subsequently validated in the 23andMe replication study.

Techniques: